منابع مشابه
Proteinuria and interstitial injury.
It has long been recognized that patients with highgrade proteinuria due to chronic glomerular disease are more likely to develop chronic renal failure than a matched group of patients with low-grade or no proteinuria [1,2]. Although this association may seem intuitively obvious, suggesting correlation with the severity of glomerular damage, two important observations promote an alternative com...
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Inhibitors of histone deacetylase (HDAC) have anti-inflammatory and antifibrotic effects in several organs and tissues, but their effect on the progression of renal disease is unknown. Here, we studied the effect of valproic acid in adriamycin-induced nephropathy in mice. Administration of valproic acid before kidney injury prevented the development of proteinuria and the onset of glomeruloscle...
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Mr. A., 73 years old, with no relevant medical history, presented in July 1992 with an abnormal chest X-ray. Physical examination revealed no particular abnormality. The CT scan showed a bulky mass (80 x 70 mm) located in the posterior segment of lower left lobe of the lung (Figure 1), mediastinal lymph node involvement and a contralateral metastatic lesion. There were no radiological sign of i...
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Meticulous blood pressure control, particularly with antiproteinuric medications, such as ACE inhibitors and angiotensin receptor blockers (ARBs), have proven to be effective in slowing the progression of kidney disease and are pillars in the modern management of chronic kidney disease (CKD). However, despite careful attention to blood pressure lowering and the use of ACEi and/or ARBs, progress...
متن کاملNephrotic-range proteinuria and interstitial nephritis associated with the use of a topical loxoprofen patch.
A 76-year-old woman with a history of lumbar fracture and marked proteinuria, bilateral pitting edema, malaise and pruritus was referred for an evaluation of an impaired renal function. A renal biopsy led to a tentative diagnosis of acute interstitial nephritis (AIN) with minimal change disease caused by nonsteroidal anti-inflammatory drugs (NSAIDs). Following the discontinuation of oral NSAIDs...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2004
ISSN: 1460-2385
DOI: 10.1093/ndt/gfg533